Research findings – The PULSES trial

Oct 27, 2023

Ultradian hydrocortisone replacement alters neuronal processing, emotional ambiguity, affect and fatigue in adrenal insufficiency: The PULSES trial

First published – 19 October 2023

“The PULSES study has shown that the pattern of cortisol presentation, even at an assumed physiological dose, influences neuronal processes – suggesting that dosage is not the only variable that is important, but that we need to recapitulate normal ultradian physiology to truly minimise side-effects.”  

 

Russell, G, Kalafatakis, K, Durant, C, Marchant, N, Thakrar, J, Thirard, R, et al. Ultradian hydrocortisone replacement alters neuronal processing, emotional ambiguity, affect and fatigue in adrenal insufficiency: The PULSES trial. J Intern Med. 2023; 00: 1–16.

Read the full paper here – http://doi.org/10.1111/joim.13721

 

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